Arterial wall fibrosis in Takayasu arteritis and its potential for therapeutic modulation

Arterial wall fibrosis in Takayasu arteritis and its potential for therapeutic modulation

Arterial wall damage in Takayasu arteritis (TAK) can progress despite immunosuppressive therapy. Vascular fibrosis is more prominent in TAK than in giant cell arteritis (GCA). The inflamed arterial wall in TAK is infiltrated by M1 macrophages [which secrete interleukin-6 (IL-6)], which transition to...

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Bibliographic Details
Main Authors: Durga Prasanna Misra, Kritika Singh, Aman Sharma, Vikas Agarwal
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
Takayasu arteritis
giant cell arteritis
fibrosis
T lymphocyte
fibroblast
mechanistic target of rapamycin complex 1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174249/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174249/full

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