Lactate-Based Model Predictive Control Strategy of Cell Growth for Cell Therapy Applications

Implementing a personalised feeding strategy for each individual batch of a bioprocess could significantly reduce the unnecessary costs of overfeeding the cells. This paper uses lactate measurements during the cell culture process as an indication of cell growth to adapt the feeding strategy accordi...

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Bibliographic Details
Main Authors: Kathleen Van Beylen, Ali Youssef, Alberto Peña Fernández, Toon Lambrechts, Ioannis Papantoniou, Jean-Marie Aerts
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Bioengineering
Subjects:
Online Access:https://www.mdpi.com/2306-5354/7/3/78