Icariin Promotes Osteogenic Differentiation in a Cell Model with NF1 Gene Knockout by Activating the cAMP/PKA/CREB Pathway

Icariin Promotes Osteogenic Differentiation in a Cell Model with NF1 Gene Knockout by Activating the cAMP/PKA/CREB Pathway

Neurofibromatosis type 1 is a rare autosomal dominant genetic disorder, with up to 50% of patients clinically displaying skeletal defects. Currently, the pathogenesis of bone disorders in NF1 patients is unclear, and there are no effective preventive and treatment measures. In this study, we found t...

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Bibliographic Details
Main Authors: Meng Chen, Lianhua Lu, Dong Cheng, Jing Zhang, Xinyong Liu, Jianli Zhang, Tianliang Zhang
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
Neurofibromatosis type 1
icariin
gene knockout
osteogenic differentiation
cAMP/PKA/CREB
Online Access:https://www.mdpi.com/1420-3049/28/13/5128

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https://www.mdpi.com/1420-3049/28/13/5128

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