mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer

mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer

Oncogenic activation of the mammalian target of rapamycin complex 1 (mTORC1) leads to endometrial cancer cell growth and proliferation. Sestrin2 (SESN2), a highly conserved stress-inducible protein, is involved in homeostatic regulation via inhibition of reactive oxygen species (ROS) and mTORC1. How...

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Bibliographic Details
Main Authors: Jiha Shin, Jeongyun Bae, Sumi Park, Hyun-Goo Kang, Seong Min Shin, Gunho Won, Jong-Seok Kim, Ssang-Goo Cho, Youngsok Choi, Sang-Muk Oh, Jongdae Shin, Jeong Sig Kim, Hwan-Woo Park
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
endometrial cancer
sestrin2
mTORC1
proliferation
migration
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/2072-6694/12/9/2515

Internet

https://www.mdpi.com/2072-6694/12/9/2515

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