Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

Abstract Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of caveolin-1 tyrosine-14 (Cav-1Y14) and ceramide generation in caveolae. Ensuing fission of caveolae yields vesicles...

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Bibliographic Details
Main Authors: V. S. Peche, T. A. Pietka, M. Jacome-Sosa, D. Samovski, H. Palacios, G. Chatterjee-Basu, A. C. Dudley, W. Beatty, G. A. Meyer, I. J. Goldberg, N. A. Abumrad
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39752-3

Internet

https://doi.org/10.1038/s41467-023-39752-3

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