Viral integration drives multifocal HCC during the occult HBV infection

Viral integration drives multifocal HCC during the occult HBV infection

Abstract Background & Aims Although the prognosis of patients with occult hepatitis B virus (HBV) infection (OBI) is usually benign, a small portion may undergo cirrhosis and subsequently hepatocellular carcinoma (HCC). We studied the mechanism of life-long Integration of virus DNA into OBI host...

Full description

Bibliographic Details
Main Authors: Xiao-Ping Chen, Xin Long, Wen-long Jia, Han-Jie Wu, Jing Zhao, Hui-Fang Liang, Arian Laurence, Jun Zhu, Dong Dong, Yan Chen, Long Lin, Yu-Dong Xia, Wei-Yang Li, Gui-Bo Li, Zhi-Kun Zhao, Kui Wu, Yong Hou, Jing-Jing Yu, Wei Xiao, Guo-Ping Wang, Peng-Cheng Zhu, Wei Chen, Ming-Zhou Bai, Yi-Xing Jian, Karsten Kristiansen, Qian Chen
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatitis B
Hepatocellular carcinoma
Single-cell sequencing
Viral integration
Virome capture sequencing
Whole genome sequencing
Online Access:http://link.springer.com/article/10.1186/s13046-019-1273-1

Internet

http://link.springer.com/article/10.1186/s13046-019-1273-1

Similar Items