Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in <i>Cyp2c70</i><sup>−/−</sup> Mice with a Human-like Bile Acid Composition

Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in <i>Cyp2c70</i><sup>−/−</sup> Mice with a Human-like Bile Acid Composition

Bile acids (BAs) and their signaling pathways have been identified as therapeutic targets for liver and metabolic diseases. We generated <i>Cyp2c70</i><sup>−/−</sup> (KO) mice that were not able to convert chenodeoxycholic acid into rodent-specific muricholic acids (MCAs) and...

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Bibliographic Details
Main Authors: Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Esther Verkade, Melany K. Veentjer, Theo H. van Dijk, Vincent W. Bloks, Rick Havinga, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomedicines
Subjects:
bile acids
colesevelam
enterohepatic circulation
liver
humanized mouse model
Online Access:https://www.mdpi.com/2227-9059/11/9/2495

Internet

https://www.mdpi.com/2227-9059/11/9/2495

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