Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in <i>Cyp2c70</i><sup>−/−</sup> Mice with a Human-like Bile Acid Composition
Bile acids (BAs) and their signaling pathways have been identified as therapeutic targets for liver and metabolic diseases. We generated <i>Cyp2c70</i><sup>−/−</sup> (KO) mice that were not able to convert chenodeoxycholic acid into rodent-specific muricholic acids (MCAs) and...
Main Authors: | Anna Palmiotti, Hilde D. de Vries, Milaine V. Hovingh, Martijn Koehorst, Niels L. Mulder, Esther Verkade, Melany K. Veentjer, Theo H. van Dijk, Vincent W. Bloks, Rick Havinga, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-09-01
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Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/11/9/2495 |
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