Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells

Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells

Using an untargeted stable isotope-assisted metabolomics approach, we identify erythronate as a metabolite that accumulates in several human cancer cell lines. Erythronate has been reported to be a detoxification product derived from off-target glycolytic metabolism. We use chemical inhibitors and g...

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Bibliographic Details
Main Authors: Jie Zhang, Mark A. Keibler, Wentao Dong, Jenny Ghelfi, Thekla Cordes, Tamara Kanashova, Arnaud Pailot, Carole L. Linster, Gunnar Dittmar, Christian M. Metallo, Tim Lautenschlaeger, Karsten Hiller, Gregory Stephanopoulos
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biomedicines
Subjects:
cancer metabolism
untargeted metabolomics
erythronate
pentose phosphate pathway
aldehyde dehydrogenase 1A1 (ALDH1A1)
Online Access:https://www.mdpi.com/2227-9059/11/10/2842

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https://www.mdpi.com/2227-9059/11/10/2842

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