Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice

Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice

ABSTRACT Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic cells (FDCs). CD21 helps activate B cells as part of...

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Bibliographic Details
Main Authors: Sarah J. Kane, Eric Swanson, Elizabeth O. Gordon, Savannah Rocha, Heather R. Bender, Luke R. Donius, Adriano Aguzzi, Jonathan P. Hannan, Mark D. Zabel
Format: Article
Language:English
Published: American Society for Microbiology 2017-12-01
Series:mSphere
Subjects:
complement receptors
prions
spleen
Online Access:https://journals.asm.org/doi/10.1128/mSphereDirect.00493-17

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https://journals.asm.org/doi/10.1128/mSphereDirect.00493-17

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