Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2,4-dione antiproliferative agents

Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2,4-dione antiproliferative agents

In this article, we display on the synthesis and biological evaluation of a new series of thiazolylpyrimidine 3a-l and thiazolidinylpyrimidine derivatives 5a-e. The structures of the new compounds were confirmed by using different spectral techniques including NMR, IR, mass spectroscopy in addition...

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Bibliographic Details
Main Authors: Ashraf A. Aly, Mohammed B. Alshammari, Akil Ahmad, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Stefan Bräse, Mahmoud A. A. Ibrahim, Asmaa H. Mohamed
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Arabian Journal of Chemistry
Subjects:
Uracil
Thiazoles
Thiazolidines
Antiproliferative
Kinases
Docking
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223000734

Internet

http://www.sciencedirect.com/science/article/pii/S1878535223000734

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