The effect of phenobarbital treatment on behavioral comorbidities and on the composition and function of the fecal microbiome in dogs with idiopathic epilepsy

The effect of phenobarbital treatment on behavioral comorbidities and on the composition and function of the fecal microbiome in dogs with idiopathic epilepsy

Phenobarbital (PB) is one of the most important antiseizure drugs (ASDs) to treat canine idiopathic epilepsy (IE). The effect of PB on the taxonomic changes in gastrointestinal microbiota (GIM) and their functions is less known, which may explain parts of its pharmacokinetic and pharmacodynamic prop...

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Bibliographic Details
Main Authors: Antja Watanangura, Sebastian Meller, Jan S. Suchodolski, Rachel Pilla, Mohammad R. Khattab, Shenja Loderstedt, Lisa F. Becker, Andrea Bathen-Nöthen, Gemma Mazzuoli-Weber, Holger A. Volk
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Veterinary Science
Subjects:
canine idiopathic epilepsy
phenobarbital
gastrointestinal microbiota
short-chain fatty acids
butyrate
behavioral comorbidities
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2022.933905/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2022.933905/full

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