Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation

Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation

Plasminogen activator inhibitor-1 (PAI-1; SERPINE1) is a prominent member of the serine protease inhibitor superfamily (SERPIN) and a causative factor of multi-organ fibrosis as well as a key regulator of the tissue repair program. PAI-1 attenuates pericellular proteolysis by inhibiting the catalyti...

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Bibliographic Details
Main Authors: Tessa M. Simone, Paul J. Higgins
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Journal of Developmental Biology
Subjects:
SERPINE1
PAI-1
migration
proliferation
pericellular proteolysis
tiplaxtinin
fibrosis
TGF-β
wound healing
apoptosis
Online Access:http://www.mdpi.com/2221-3759/3/1/11

Internet

http://www.mdpi.com/2221-3759/3/1/11

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