Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation
Plasminogen activator inhibitor-1 (PAI-1; SERPINE1) is a prominent member of the serine protease inhibitor superfamily (SERPIN) and a causative factor of multi-organ fibrosis as well as a key regulator of the tissue repair program. PAI-1 attenuates pericellular proteolysis by inhibiting the catalyti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | http://www.mdpi.com/2221-3759/3/1/11 |
| _version_ | 1818499600131031040 |
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| author | Tessa M. Simone Paul J. Higgins |
| author_facet | Tessa M. Simone Paul J. Higgins |
| author_sort | Tessa M. Simone |
| collection | DOAJ |
| description | Plasminogen activator inhibitor-1 (PAI-1; SERPINE1) is a prominent member of the serine protease inhibitor superfamily (SERPIN) and a causative factor of multi-organ fibrosis as well as a key regulator of the tissue repair program. PAI-1 attenuates pericellular proteolysis by inhibiting the catalytic activity of both urokinase and tissue-type protease activators (uPA and tPA) effectively modulating, thereby, plasmin-mediated fibrinolysis and the overall pericellular proteolytic cascade. PAI-1 also impacts cellular responses to tissue injury and stress situations (growth, survival, migration) by titering the locale and temporal activation of multimeric cell-surface signaling complexes. This review will describe PAI-1 structure and function and detail the role of PAI-1 in the tissue repair program with an emphasis on cutaneous wound healing. |
| first_indexed | 2024-12-10T20:31:42Z |
| format | Article |
| id | doaj.art-6f350c381d4a42a7a322e41ce7be6a7d |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-12-10T20:31:42Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-6f350c381d4a42a7a322e41ce7be6a7d2022-12-22T01:34:40ZengMDPI AGJournal of Developmental Biology2221-37592015-03-0131112410.3390/jdb3010011jdb3010011Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue FormationTessa M. Simone0Paul J. Higgins1Center for Cell Biology & Cancer Research, Albany Medical College, Albany, New York, NY 12208, USACenter for Cell Biology & Cancer Research, Albany Medical College, Albany, New York, NY 12208, USAPlasminogen activator inhibitor-1 (PAI-1; SERPINE1) is a prominent member of the serine protease inhibitor superfamily (SERPIN) and a causative factor of multi-organ fibrosis as well as a key regulator of the tissue repair program. PAI-1 attenuates pericellular proteolysis by inhibiting the catalytic activity of both urokinase and tissue-type protease activators (uPA and tPA) effectively modulating, thereby, plasmin-mediated fibrinolysis and the overall pericellular proteolytic cascade. PAI-1 also impacts cellular responses to tissue injury and stress situations (growth, survival, migration) by titering the locale and temporal activation of multimeric cell-surface signaling complexes. This review will describe PAI-1 structure and function and detail the role of PAI-1 in the tissue repair program with an emphasis on cutaneous wound healing.http://www.mdpi.com/2221-3759/3/1/11SERPINE1PAI-1migrationproliferationpericellular proteolysistiplaxtininfibrosisTGF-βwound healingapoptosis |
| spellingShingle | Tessa M. Simone Paul J. Higgins Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation Journal of Developmental Biology SERPINE1 PAI-1 migration proliferation pericellular proteolysis tiplaxtinin fibrosis TGF-β wound healing apoptosis |
| title | Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation |
| title_full | Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation |
| title_fullStr | Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation |
| title_full_unstemmed | Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation |
| title_short | Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation |
| title_sort | inhibition of serpine1 function attenuates wound closure in response to tissue injury a role for pai 1 in re epithelialization and granulation tissue formation |
| topic | SERPINE1 PAI-1 migration proliferation pericellular proteolysis tiplaxtinin fibrosis TGF-β wound healing apoptosis |
| url | http://www.mdpi.com/2221-3759/3/1/11 |
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