Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease

Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease

With an aging population, kidney health becomes an important medical and socioeconomic factor. Kidney aging mechanisms are not well understood. We previously showed that podocytes isolated from aged mice exhibit increased expression of programmed cell death protein 1 (PD-1) surface receptor and its...

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Bibliographic Details
Main Authors: Jeffrey W. Pippin, Natalya Kaverina, Yuliang Wang, Diana G. Eng, Yuting Zeng, Uyen Tran, Carol J. Loretz, Anthony Chang, Shreeram Akilesh, Chetan Poudel, Hannah S. Perry, Christopher O’Connor, Joshua C. Vaughan, Markus Bitzer, Oliver Wessely, Stuart J. Shankland
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-08-01
Series:The Journal of Clinical Investigation
Subjects:
Aging
Online Access:https://doi.org/10.1172/JCI156250

Internet

https://doi.org/10.1172/JCI156250

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