Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells

Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells

The purine derivative fludarabine is part of frontline therapy for chronic lymphocytic leukaemia (CLL). It has shown positive effects on solid tumours such as melanoma, breast, and colon carcinoma in clinical phase I studies. As the treatment of CLL cells with combinations of fludarabine and metal c...

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Bibliographic Details
Main Authors: Sebastian W. Schleser, Oleksandr Krytovych, Tim Ziegelmeier, Elisabeth Groß, Jana Kasparkova, Viktor Brabec, Thomas Weber, Rainer Schobert, Thomas Mueller
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
anticancer drugs
CLL
fludarabine
lymphoma
metal–drug synergy
platinum complexes
Online Access:https://www.mdpi.com/1420-3049/28/13/5173

Internet

https://www.mdpi.com/1420-3049/28/13/5173

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