Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma

Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma

Glioblastoma (GBM) is the most malignant tumor of the central nervous system in adults. Irradiation (IR) and temozolomide (TMZ) play an extremely important role in the treatment of GBM. However, major impediments to effective treatment are postoperative tumor recurrence and acquired resistance to ch...

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Bibliographic Details
Main Authors: Xiao Liu, Zhengcong Cao, Nannan Liu, Guangxun Gao, Mingrui Du, Yingwen Wang, Boyang Cheng, Maorong Zhu, Bo Jia, Luxiang Pan, Wangqian Zhang, Yuran Jiang, Wei He, Linlin Xu, Wei Zhang, Qunxing An, Qingdong Guo, Jintao Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma
Yin Yang 1
T7
exosome
chemoradiotherapy sensitization
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.975291/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.975291/full

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