Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Abstract Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest that there may be a link between cholesterol levels and AD pathology. Since cholesterol is one of the most ab...

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Bibliographic Details
Main Authors: Vladimir Rudajev, Jiri Novotny
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell & Bioscience
Subjects:
Amyloid β
Amyloid precursor protein
Amyloidogenesis
Cholesterol
Secretase
Online Access:https://doi.org/10.1186/s13578-023-01127-y

Internet

https://doi.org/10.1186/s13578-023-01127-y

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