An IFN-STAT Axis Augments Tissue Damage and Inflammation in a Mouse Model of Crohn's Disease

An IFN-STAT Axis Augments Tissue Damage and Inflammation in a Mouse Model of Crohn's Disease

Blocking interferon-function by therapeutic intervention of the JAK-STAT-axis is a novel promising treatment option for inflammatory bowel disease (IBD). Although JAK inhibitors have proven efficacy in patients with active ulcerative colitis (UC), they failed to induce clinical remission in patients...

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Bibliographic Details
Main Authors: Iris Stolzer, Anja Dressel, Mircea T. Chiriac, Markus F. Neurath, Claudia Günther
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Medicine
Subjects:
inflammatory bowel disease
STAT signaling
inflammation
cell death
Paneth cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.644244/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.644244/full

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