Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis

Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis

Abstract Overproduction of reactive oxygen species (ROS) and aberrant lipid metabolism are established hallmarks of cancer; however, the role of ROS in lipid synthesis during tumorigenesis is almost unknown. Herein, we show that ROS regulates lipid synthesis and thus controls colorectal tumorigenesi...

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Bibliographic Details
Main Authors: Zelong Han, Ming Liu, Yuxin Xie, Kunlin Zeng, Ziling Zhan, Yanwen Chen, Li Wang, Xiaoxia Chen, Yaxin Luo, Yu Zeng, Hongchao Zhan, Yingzhuo Lin, Keqin Zhang, Xiaoxia Zhu, Side Liu, Xiaobei Luo, Aidong Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01241-9

Internet

https://doi.org/10.1038/s41420-022-01241-9

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