Improving analysis of cognitive outcomes in cardiovascular trials using different statistical approaches

Improving analysis of cognitive outcomes in cardiovascular trials using different statistical approaches

Abstract Background The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) questionnaires are commonly used to measure global cognition in clinical trials. Because these scales are discrete and bounded with ceiling and floor effects and highly skewed, their analysis as...

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Bibliographic Details
Main Authors: Shun Fu Lee, William Whiteley, Jackie Bosch, Laura Sherlock, Tali Cukierman-Yaffe, Martin O’Donnell, John W. Eikelboom, Hertzel C. Gerstein, Shrikant I. Bangdiwala, Graciela Muniz-Terrera
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Trials
Subjects:
Bounded
Ceiling effect
Cognitive
Generalized linear regression
Beta-binomial
Tobit
Online Access:https://doi.org/10.1186/s13063-024-08482-2

Internet

https://doi.org/10.1186/s13063-024-08482-2

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