Deletion of <i>Gadd45a</i> Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer’s Disease Hallmarks

Deletion of <i>Gadd45a</i> Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer’s Disease Hallmarks

<i>Gadd45</i> genes have been implicated in survival mechanisms, including apoptosis, autophagy, cell cycle arrest, and DNA repair, which are processes related to aging and life span. Here, we analyzed if the deletion of <i>Gadd45a</i> activates pathways involved in neurodege...

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Bibliographic Details
Main Authors: Christian Griñán-Ferré, Júlia Jarne-Ferrer, Aina Bellver-Sanchis, Marta Ribalta-Vilella, Emma Barroso, Jesús M. Salvador, Javier Jurado-Aguilar, Xavier Palomer, Manuel Vázquez-Carrera, Mercè Pallàs
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
cognitive impairment
Alzheimer’s disease
Tau pathology
neuroinflammation
<i>Gadd45a</i>
Online Access:https://www.mdpi.com/1422-0067/25/5/2595

Internet

https://www.mdpi.com/1422-0067/25/5/2595

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