Divergent signaling requirements of dSARM in injury-induced degeneration and developmental glial phagocytosis.

Divergent signaling requirements of dSARM in injury-induced degeneration and developmental glial phagocytosis.

Elucidating signal transduction mechanisms of innate immune pathways is essential to defining how they elicit distinct cellular responses. Toll-like receptors (TLR) signal through their cytoplasmic TIR domains which bind other TIR domain-containing adaptors. dSARM/SARM1 is one such TIR domain adapto...

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Bibliographic Details
Main Authors: Kelsey A Herrmann, Yizhou Liu, Arnau Llobet-Rosell, Colleen N McLaughlin, Lukas J Neukomm, Jaeda C Coutinho-Budd, Heather T Broihier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010257

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https://doi.org/10.1371/journal.pgen.1010257

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