The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.

The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.

Cohesion between sister chromatids is essential for faithful chromosome segregation. In budding yeast, the acetyltransferase Eco1/Ctf7 establishes cohesion during DNA replication in S phase and in response to DNA double strand breaks in G2/M phase. In humans two Eco1 orthologs exist: ESCO1 and ESCO2...

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Main Authors: Petra van der Lelij, Barbara C Godthelp, Wouter van Zon, Djoke van Gosliga, Anneke B Oostra, Jûrgen Steltenpool, Jan de Groot, Rik J Scheper, Rob M Wolthuis, Quinten Waisfisz, Firouz Darroudi, Hans Joenje, Johan P de Winter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2734174?pdf=render

Internet

http://europepmc.org/articles/PMC2734174?pdf=render

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