Photoreceptor Degeneration in Pro23His Transgenic Rats (Line 3) Involves Autophagic and Necroptotic Mechanisms

Photoreceptor Degeneration in Pro23His Transgenic Rats (Line 3) Involves Autophagic and Necroptotic Mechanisms

Photoreceptor death contributes to 50% of irreversible vision loss in the western world. Pro23His (P23H) transgenic albino rat strains are widely used models for the most common rhodopsin gene mutation associated with the autosomal dominant form of retinitis pigmentosa. However, the mechanism(s) by...

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Bibliographic Details
Main Authors: Kiana Kakavand, Andrew I. Jobling, Ursula Greferath, Kirstan A. Vessey, Robb U. de Iongh, Erica L. Fletcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
apoptosis
autophagy
cell death
necroptosis
retinitis pigmentosa photoreceptor
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.581579/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.581579/full

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