A novel in vitro cell model of the proteinase/antiproteinase balance observed in alpha-1 antitrypsin deficiency
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting from mutations in the alpha-1 antitrypsin (AAT) protein, a major systemic antiproteinase, resulting in reduced/no release of AAT, disrupting the proteinase/antiproteinase balance. A sustained imbalance can cause struc...
| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado: |
Frontiers Media S.A.
2024-07-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Acceso en liña: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1421598/full |