Impact of simulated brain interstitial fluid flow on the chemokine CXCL12 release from an alginate-based hydrogel in a new 3D in vitro model

Impact of simulated brain interstitial fluid flow on the chemokine CXCL12 release from an alginate-based hydrogel in a new 3D in vitro model

Introduction: Extensive investigation has been undertaken regarding drug delivery systems for the management of glioblastoma multiforme (GBM). The infiltrative behavior of GBM cells within the brain tissue is primarily attributed to their heterogeneity, the movement of interstitial fluid (IFF), and...

Full description

Bibliographic Details
Main Authors: Wiam El Kheir, Anaïs Dumais, Maude Beaudoin, Bernard Marcos, Nick Virgilio, Benoit Paquette, Nathalie Faucheux, Marc-Antoine Lauzon
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Drug Delivery
Subjects:
glioblastoma multiforme
nanoparticles
chemokines gradient
kinetic release
mathematical modeling
3D delivery system
Online Access:https://www.frontiersin.org/articles/10.3389/fddev.2023.1227776/full

Internet

https://www.frontiersin.org/articles/10.3389/fddev.2023.1227776/full

Similar Items