Interaction Interface of Aβ<sub>42</sub> with Human Na,K-ATPase Studied by MD and ITC and Inhibitor Screening by MD

Interaction Interface of Aβ<sub>42</sub> with Human Na,K-ATPase Studied by MD and ITC and Inhibitor Screening by MD

Alzheimer’s disease (AD) is a neurodegenerative disease accompanied by progressive cognitive and memory dysfunction due to disruption of normal electrotonic properties of neurons and neuronal loss. The Na,K-ATPase interaction with beta amyloid (Aβ) plays an important role in AD pathogenesis. It has...

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Bibliographic Details
Main Authors: Alexei A. Adzhubei, Anna P. Tolstova, Maria A. Strelkova, Vladimir A. Mitkevich, Irina Yu. Petrushanko, Alexander A. Makarov
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
Alzheimer’s disease
Na,K-ATPase
beta amyloid
interaction interface
interaction inhibitors screening
conformations of Na,K-ATPase
Online Access:https://www.mdpi.com/2227-9059/10/7/1663

Internet

https://www.mdpi.com/2227-9059/10/7/1663

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