Oncolytic Adenoviral Vector-Mediated Expression of an Anti-PD-L1-scFv Improves Anti-Tumoral Efficacy in a Melanoma Mouse Model

Oncolytic Adenoviral Vector-Mediated Expression of an Anti-PD-L1-scFv Improves Anti-Tumoral Efficacy in a Melanoma Mouse Model

Oncolytic virotherapy is an emerging therapeutic approach based on replication-competent viruses able to selectively infect and destroy cancer cells, inducing the release of tumor-associated antigens and thereby recruiting immune cells with a subsequent increase in antitumoral immune response. To in...

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Bibliographic Details
Main Authors: Maria Vitale, Filippo Scialò, Margherita Passariello, Eleonora Leggiero, Anna D’Agostino, Lorella Tripodi, Laura Gentile, Andrea Bianco, Giuseppe Castaldo, Vincenzo Cerullo, Claudia De Lorenzo, Lucio Pastore
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
oncolytic virotherapy
oncolytic adenoviruses
programmed death ligand 1 (PD-L1)
Programmed cell death 1 (PD-1)
single-chain variable antibody fragment (scFv)
B16.OVA cells
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.902190/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.902190/full

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