Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas.

Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas.

BACKGROUND: Papillary thyroid carcinoma (PTCs), the most frequent thyroid cancer, is usually not life threatening, but may recur or progress to aggressive forms resistant to conventional therapies. A more detailed understanding of the signaling pathways activated in PTCs may help to identify novel t...

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Bibliographic Details
Main Authors: Debora Degl'Innocenti, Chiara Alberti, Giancarlo Castellano, Angela Greco, Claudia Miranda, Marco A Pierotti, Ettore Seregni, Maria Grazia Borrello, Silvana Canevari, Antonella Tomassetti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2943897?pdf=render

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http://europepmc.org/articles/PMC2943897?pdf=render

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