G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis

G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis

Abstract Background Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen dependence, suggest that estrogen receptors (ERs) contribute to the develop...

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Bibliographic Details
Main Authors: Jiaping Chen, Rong Zhao, Yangwei Wang, Han Xiao, Wei Lin, Mingxin Diao, Shiwen He, Peiyuan Mei, Yongde Liao
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Molecular Medicine
Subjects:
NSCLC
GPER1
Ferroptosis
Cisplatin and SCD1
Online Access:https://doi.org/10.1186/s10020-023-00763-x

Internet

https://doi.org/10.1186/s10020-023-00763-x

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