Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral Particles

Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral Particles

Human SP-D is a potent innate immune molecule whose presence at pulmonary mucosal surfaces allows its role in immune surveillance against pathogens. Higher levels of serum SP-D have been reported in the patients with severe acute respiratory syndrome coronavirus (SARS-CoV). Studies have suggested th...

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Bibliographic Details
Main Authors: Miao-Hsi Hsieh, Nazar Beirag, Valarmathy Murugaiah, Yu-Chi Chou, Wen-Shuo Kuo, Hui-Fang Kao, Taruna Madan, Uday Kishore, Jiu-Yao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
innate immunity
SARS-COV-2
spike protein
human pulmonary collectins
surfactant protein D
angiotensin converting enzyme 2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.641360/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.641360/full

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