Molecular design of orthogonal stacking system at the complex interface of HtrA PDZ domain with its peptide ligands

Molecular design of orthogonal stacking system at the complex interface of HtrA PDZ domain with its peptide ligands

The high temperature requirement A (HtrA) protease plays a crucial role in protein quality control and cell fate. The enzyme contains a catalytic protease domain and a regulatory PDZ domain; the latter determines the substrate specificity of the former by specifically binding to the C-terminal hydro...

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Bibliographic Details
Main Authors: Zhang Dingwa, He Deyong, Pan Xiaoliang, Xu Yaping, Liu Lijun
Format: Article
Language:English
Published: Serbian Chemical Society 2019-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
htra protease
htra pdz domain
peptide ligand
orthogonal π-cation-π stacking
synergistic effect
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391900029Z.pdf

Internet

http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391900029Z.pdf

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