NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition

NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition

Abstract Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment. Here, cancer cell lines sensitive or resistant to OXPHOS inhibition are identified by sc...

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Bibliographic Details
Main Authors: Changqing Wu, Yu'e Liu, Wenju Liu, Tianhui Zou, Shaojuan Lu, Chengjie Zhu, Le He, Jie Chen, Lan Fang, Lin Zou, Ping Wang, Lihong Fan, Hongxiang Wang, Han You, Juxiang Chen, Jing‐Yuan Fang, Cizhong Jiang, Yufeng Shi
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Advanced Science
Subjects:
biomarker
cancer
DNA methylation
N‐methyltransferase (NNMT)
oxidative phosphorylation (OXPHOS)
S‐adenosyl methionine (SAM)
Online Access:https://doi.org/10.1002/advs.202202642

Internet

https://doi.org/10.1002/advs.202202642

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