Structure-based strategies for synthesis, lead optimization and biological evaluation of N-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as potential multi-target anticancer agents

Structure-based strategies for synthesis, lead optimization and biological evaluation of N-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as potential multi-target anticancer agents

As part of our research on developing multi-target small molecule anticancer agents, we designed, synthesized, and biologically evaluated a series of novel diversified analogues based on our thiadiazole-fused anthraquinone lead compound NSC745885. We initially screened our compounds based on their c...

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Bibliographic Details
Main Authors: Ahmed Atef Ahmed Ali, Yu-Ru Lee, Alexander T.H. Wu, Vijesh Kumar Yadav, Dah-Shyong Yu, Hsu-Shan Huang
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Arabian Journal of Chemistry
Subjects:
Apoptosis
Cell cycle
Cyclin D1
COX-2
Topoisomerase
Thiadiazole-fused anthraquinone derivative
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535220304366

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http://www.sciencedirect.com/science/article/pii/S1878535220304366

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