Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions

Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions

Mycobacterium tuberculosis (M. tb) persists as latent infection in nearly a quarter of the global population and remains the leading cause of death among infectious diseases. While BCG is the only vaccine for TB, its inability to provide complete protection makes it imperative to engineer BCG such t...

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Bibliographic Details
Main Authors: Simran Kaur Arora, Anwar Alam, Nilofer Naqvi, Javeed Ahmad, Javaid Ahmad Sheikh, Syed Asad Rahman, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
CD4+/CD8+ T cells
central memory
effector memory
Mycobacterium smegmatis knock-in
TB subunit vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01199/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01199/full

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