Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis

A prevalent feature of Strongyloides stercoralis is a life-long and potentially lethal infection that is due to the nematode parasite’s ability to autoinfect and, thereby, self-replicate within its host. Here, we investigated the role of the parasite’s nuclear receptor, Ss-DAF-12, in governing infec...

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Bibliographic Details
Main Authors: Zhu Wang, Mi Cheong Cheong, Jet Tsien, Heping Deng, Tian Qin, Jonathan DC Stoltzfus, Tegegn G Jaleta, Xinshe Li, James B Lok, Steven A Kliewer, David J Mangelsdorf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
nematode parasitism
Strongyloides stercoralis
DAF-12
nuclear receptor
ivermectin
gerbil
Online Access:https://elifesciences.org/articles/73535

Internet

https://elifesciences.org/articles/73535

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