Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response

Cancer therapy: Limiting responses to DNA damage Protein interactions that protect cells from excessive responses to DNA damage may help improve cancer treatments. Normal metabolic processes and environmental factors such as exposure to radiation can damage DNA within cells. Excessive responses to s...

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Bibliographic Details
Main Authors: Jiyun Kwon, Suhee Lee, Yong-Nyun Kim, In Hye Lee
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-019-0232-4