Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells

Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells

Abstract Background Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells (MSCs). Mechanisms directing obesity-induced phenotypic alterations in MSCs remain unclear, but emerging drivers include...

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Bibliographic Details
Main Authors: Logan M. Glasstetter, Tomiwa S. Oderinde, Mohit Mirchandani, Kamalnath Sankaran Rajagopalan, Samer H. Barsom, Roman Thaler, Sarosh Siddiqi, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Andre J. van Wijnen, Alfonso Eirin, Lilach O. Lerman
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem/stromal cells
Epigenetics
Hydroxymethylation
Apoptosis
Senescence
Obesity
Online Access:https://doi.org/10.1186/s13287-023-03372-x

Internet

https://doi.org/10.1186/s13287-023-03372-x

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