Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS--A Novel Therapeutic Opportunity.

Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS--A Novel Therapeutic Opportunity.

IdeS is a streptococcal protease that cleaves IgG antibodies into F(ab’)2 and Fc fragments with a unique degree of specificity, thereby providing a novel treatment opportunity of IgG-driven autoimmune conditions and antibody mediated transplant rejection. Here we report the results from a first in m...

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Bibliographic Details
Main Authors: Lena Winstedt, Sofia Järnum, Emma Andersson Nordahl, Andreas Olsson, Anna Runström, Robert Bockermann, Christofer Karlsson, Johan Malmström, Gabriella Samuelsson Palmgren, Ulf Malmqvist, Lars Björck, Christian Kjellman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4503742?pdf=render

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http://europepmc.org/articles/PMC4503742?pdf=render

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