Piezo1 Regulation Involves Lipid Domains and the Cytoskeleton and Is Favored by the Stomatocyte–Discocyte–Echinocyte Transformation

Piezo1 Regulation Involves Lipid Domains and the Cytoskeleton and Is Favored by the Stomatocyte–Discocyte–Echinocyte Transformation

Piezo1 is a mechanosensitive ion channel required for various biological processes, but its regulation remains poorly understood. Here, we used erythrocytes to address this question since they display Piezo1 clusters, a strong and dynamic cytoskeleton and three types of submicrometric lipid domains,...

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Bibliographic Details
Main Authors: Amaury Stommen, Marine Ghodsi, Anne-Sophie Cloos, Louise Conrard, Andra C. Dumitru, Patrick Henriet, Christophe E. Pierreux, David Alsteens, Donatienne Tyteca
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomolecules
Subjects:
Piezo1 distribution
Piezo1 chemical activation
Yoda1
membrane stiffness
erythrocyte morphology
cholesterol
Online Access:https://www.mdpi.com/2218-273X/14/1/51

Internet

https://www.mdpi.com/2218-273X/14/1/51

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