Neural reprogramming via microRNAs: the new kid on the p53-deficient block
We recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. This directed sensory nerve reprogramming in the tumor microenvironment which enhanced...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1756723 |
| _version_ | 1827809344298680320 |
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| author | Deborah A. Silverman George A. Calin Jeffrey N. Myers Moran Amit |
| author_facet | Deborah A. Silverman George A. Calin Jeffrey N. Myers Moran Amit |
| author_sort | Deborah A. Silverman |
| collection | DOAJ |
| description | We recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. This directed sensory nerve reprogramming in the tumor microenvironment which enhanced tumor growth. |
| first_indexed | 2024-03-11T22:40:44Z |
| format | Article |
| id | doaj.art-6f6f2afd0dea40e3ad4764fa281f25b2 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:44Z |
| publishDate | 2020-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-6f6f2afd0dea40e3ad4764fa281f25b22023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-07-017410.1080/23723556.2020.17567231756723Neural reprogramming via microRNAs: the new kid on the p53-deficient blockDeborah A. Silverman0George A. Calin1Jeffrey N. Myers2Moran Amit3The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer CenterWe recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. This directed sensory nerve reprogramming in the tumor microenvironment which enhanced tumor growth.http://dx.doi.org/10.1080/23723556.2020.1756723tp53p53neural reprogrammingadrenergic signalinghead and neck cancertumor microenvironmentmir-34amicrorna |
| spellingShingle | Deborah A. Silverman George A. Calin Jeffrey N. Myers Moran Amit Neural reprogramming via microRNAs: the new kid on the p53-deficient block Molecular & Cellular Oncology tp53 p53 neural reprogramming adrenergic signaling head and neck cancer tumor microenvironment mir-34a microrna |
| title | Neural reprogramming via microRNAs: the new kid on the p53-deficient block |
| title_full | Neural reprogramming via microRNAs: the new kid on the p53-deficient block |
| title_fullStr | Neural reprogramming via microRNAs: the new kid on the p53-deficient block |
| title_full_unstemmed | Neural reprogramming via microRNAs: the new kid on the p53-deficient block |
| title_short | Neural reprogramming via microRNAs: the new kid on the p53-deficient block |
| title_sort | neural reprogramming via micrornas the new kid on the p53 deficient block |
| topic | tp53 p53 neural reprogramming adrenergic signaling head and neck cancer tumor microenvironment mir-34a microrna |
| url | http://dx.doi.org/10.1080/23723556.2020.1756723 |
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