Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial
Abstract Background Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged m...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Nutrition |
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| Online Access: | https://doi.org/10.1186/s40795-021-00482-8 |
| _version_ | 1818992129652817920 |
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| author | Siv K. Bøhn Mari C. W. Myhrstad Magne Thoresen Iris Erlund Ann Kristin Vasstrand Anne Marciuch Monica H. Carlsen Nasser E. Bastani Knut Engedal Kjell M. Flekkøy Rune Blomhoff |
| author_facet | Siv K. Bøhn Mari C. W. Myhrstad Magne Thoresen Iris Erlund Ann Kristin Vasstrand Anne Marciuch Monica H. Carlsen Nasser E. Bastani Knut Engedal Kjell M. Flekkøy Rune Blomhoff |
| author_sort | Siv K. Bøhn |
| collection | DOAJ |
| description | Abstract Background Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment. Methods Nine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention. Results Compared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]). Conclusions The results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established. Trial registration Registration number ( ClinicalTrials.gov : NCT00972972 ), September 9, 2009. |
| first_indexed | 2024-12-20T20:21:15Z |
| format | Article |
| id | doaj.art-6f7334a9fb0642219ac8cf5dcf9c894f |
| institution | Directory Open Access Journal |
| issn | 2055-0928 |
| language | English |
| last_indexed | 2024-12-20T20:21:15Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nutrition |
| spelling | doaj.art-6f7334a9fb0642219ac8cf5dcf9c894f2022-12-21T19:27:34ZengBMCBMC Nutrition2055-09282021-11-017111710.1186/s40795-021-00482-8Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trialSiv K. Bøhn0Mari C. W. Myhrstad1Magne Thoresen2Iris Erlund3Ann Kristin Vasstrand4Anne Marciuch5Monica H. Carlsen6Nasser E. Bastani7Knut Engedal8Kjell M. Flekkøy9Rune Blomhoff10Department of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life SciencesDepartment of Nutrition, Faculty of Health Sciences, Oslo Metropolitan UniversityDepartment of Biostatistics, Institute of Basic Medical SciencesDepartment of Government Services, Finnish Institute for Health and WelfareDepartment of Psychology, University of OsloDepartment of Psychology, University of OsloDepartment of Nutrition, Institute of Basic Medical Sciences, University of OsloDepartment of Nutrition, Institute of Basic Medical Sciences, University of OsloDepartment of geriatric medicine, Oslo university hospitalDepartment of Psychology, University of OsloDepartment of Nutrition, Institute of Basic Medical Sciences, University of OsloAbstract Background Few randomized clinical trials have explored the health effects of bilberries in humans. The aim was to test the effect of bilberry and red grape-juice consumption on visual memory, motor speed and dexterity as well as inflammatory and tissue damage biomarkers of plasma in aged men with subjective memory impairment. Methods Nine-week double-blind, placebo-controlled, dietary intervention study of aged men (n = 60, age ≥ 67 years) with subjective memory impairment randomized to consume a 50/50 mix of bilberry/red grape-juice or an iso-caloric placebo juice. A selection of Cambridge Cognition Test Battery (CANTAB), Grooved Pegboard tests and blood-sampling for biomarker analysis were performed before and after the intervention. Results Compared to placebo the selected memory and motor test scores were un-affected by the bilberry/red grape intervention. However, the plasma levels of tissue damage biomarkers decreased significantly more in the bilberry/red grape group. In particular lactate dehydrogenase (LDH) decreased from 362 U/L (median, baseline) to 346 U/L (median, post intervention) in the bilberry/red grape group. Also, several biomarkers of inflammation (EGF, IL6, IL9, IL10 and TNFα) decreased significantly more in the bilberry/red grape group. Furthermore, several plasma polyphenols; p-coumaric acid, hippuric acid, protocatechuic acid, 3HPAA and vanillic acid, increased significantly more in the bilberry/red grape group compared to placebo with the largest increase in p-coumaric acid with 116%; from 2.2 [1.0,5.5] to 4.7 [2.8,8.1] μM/L (median [95% CL]). Conclusions The results indicate that a nine-week bilberry/red grape juice intervention has no measurable effects on the selected memory scores in aged men experiencing memory problems but decreases the level of biomarkers of inflammation and tissue damage. Whether the dampening effects on inflammation and tissue damage biomarkers have relevance for neuroinflammatory brain pathology remains to be established. Trial registration Registration number ( ClinicalTrials.gov : NCT00972972 ), September 9, 2009.https://doi.org/10.1186/s40795-021-00482-8Bilberry; blueberry; blueberriesGrapeCytokinesMemoryInflammationAged men |
| spellingShingle | Siv K. Bøhn Mari C. W. Myhrstad Magne Thoresen Iris Erlund Ann Kristin Vasstrand Anne Marciuch Monica H. Carlsen Nasser E. Bastani Knut Engedal Kjell M. Flekkøy Rune Blomhoff Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial BMC Nutrition Bilberry; blueberry; blueberries Grape Cytokines Memory Inflammation Aged men |
| title | Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial |
| title_full | Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial |
| title_fullStr | Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial |
| title_full_unstemmed | Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial |
| title_short | Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial |
| title_sort | bilberry red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment a randomized clinical trial |
| topic | Bilberry; blueberry; blueberries Grape Cytokines Memory Inflammation Aged men |
| url | https://doi.org/10.1186/s40795-021-00482-8 |
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