A highly susceptible hACE2-transgenic mouse model for SARS-CoV-2 research

A highly susceptible hACE2-transgenic mouse model for SARS-CoV-2 research

Several animal models have been used to assist the development of vaccines and therapeutics since the COVID-19 outbreak. Due to the lack of binding affinity of mouse angiotensin-converting enzyme II (ACE2) to the S protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), increasing t...

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Bibliographic Details
Main Authors: Gang Liu, Min Zhang, Baolei Wu, Cheng Zhang, Yan Wang, Xuelian Han, Rongjuan Wang, Li Li, Yuwei Wei, Yali Sun, Xiangwen Cao, Yuan Wang, Yalan Li, Min Li, Guangyu Zhao, Yuehua Ke, Zhendong Guo, Qi Yin, Yansong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Microbiology
Subjects:
ACE2
inflammatory response
lung injury
mouse model
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1348405/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2024.1348405/full

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