The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model.

The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model.

Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, occasionally causes severe neurological symptoms. We identified P-selectin glycoprotein ligand-1 (PSGL-1) as an EV71 receptor and found that an amino acid residue 145 in the capsid protein VP1 (VP1-145) defined PSGL-1-b...

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Bibliographic Details
Main Authors: Chikako Kataoka, Tadaki Suzuki, Osamu Kotani, Naoko Iwata-Yoshikawa, Noriyo Nagata, Yasushi Ami, Takaji Wakita, Yorihiro Nishimura, Hiroyuki Shimizu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4504482?pdf=render

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http://europepmc.org/articles/PMC4504482?pdf=render

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