Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

Cancer cachexia (CC), a wasting syndrome of muscle and adipose tissue resulting in weight loss, is observed in 50% of patients with solid tumors. Management of CC is limited by the absence of biomarkers and knowledge of molecules that drive its phenotype. To identify such molecules, we injected 54 h...

Full description

Bibliographic Details
Main Authors: Puneeth Iyengar, Aakash Y. Gandhi, Jorge Granados, Tong Guo, Arun Gupta, Jinhai Yu, Ernesto M. Llano, Faya Zhang, Ang Gao, Asha Kandathil, Dorothy Williams, Boning Gao, Luc Girard, Venkat S. Malladi, John M. Shelton, Bret M. Evers, Raquibul Hannan, Chul Ahn, John D. Minna, Rodney E. Infante
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-04-01
Series:JCI Insight
Subjects:
Metabolism
Oncology
Online Access:https://doi.org/10.1172/jci.insight.165419

Internet

https://doi.org/10.1172/jci.insight.165419

Similar Items