Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies

Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies

Abstract In a pilot study, we evaluated the feasibility of real-time deep analysis of serial tumor samples from triple negative breast cancer patients to identify mechanisms of resistance and treatment opportunities as they emerge under therapeutic stress engendered by poly-ADP-ribose polymerase (PA...

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Main Authors: Marilyne Labrie, Allen Li, Allison Creason, Courtney Betts, Jamie Keck, Brett Johnson, Shamilene Sivagnanam, Christopher Boniface, Hongli Ma, Aurora Blucher, Young Hwan Chang, Koei Chin, Jacqueline Vuky, Alexander R. Guimaraes, Molly Downey, Jeong Youn Lim, Lina Gao, Kiara Siex, Swapnil Parmar, Annette Kolodzie, Paul T. Spellman, Jeremy Goecks, Lisa M. Coussens, Christopher L. Corless, Raymond Bergan, Joe W. Gray, Gordon B. Mills, Zahi I. Mitri
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-021-00232-w

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https://doi.org/10.1038/s41698-021-00232-w

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