Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels

BackgroundHaemostasis is a crucial process by which the body stops bleeding. It is achieved by the formation of a platelet plug, which is strengthened by formation of a fibrin mesh mediated by the coagulation cascade. In proinflammatory and prothrombotic conditions, multiple interactions of the comp...

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Bibliographic Details
Main Authors: Murielle Golomingi, Jessie Kohler, Christina Lamers, Richard B. Pouw, Daniel Ricklin, József Dobó, Péter Gál, Gábor Pál, Bence Kiss, Arthur Dopler, Christoph Q. Schmidt, Elaissa Trybus Hardy, Wilbur Lam, Verena Schroeder
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
haemostasis
complement system
MBL-associated serine protease-2 (MASP-2)
complement C1s
complement factor D (FD)
complement C3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1226832/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1226832/full

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