Characterization of cryptic complex chromosome rearrangements in balanced chromosomal rearrangement carriers and their PGT-SR clinical outcome assessments

Characterization of cryptic complex chromosome rearrangements in balanced chromosomal rearrangement carriers and their PGT-SR clinical outcome assessments

Abstract Several reports have presented that balanced chromosomal rearrangements (BCRs) carriers with normal phenotypes may be carriers of complex rearrangements. However, the incidence and PGT clinical outcomes of cryptic complex chromosome rearrangements (CCCRs) in individuals with BCRs is remain...

Full description

Bibliographic Details
Main Authors: Dehua Cheng, Hebatallah Ibrahim, Keli Luo, Yifan Gu, Pingyuan Xie, Yanqin Xiao, Jingpeng Cai, Xianhong Wu, Ge Lin, Yueqiu Tan, Liang Hu
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Scientific Reports
Subjects:
Balanced chromosome rearrangment (BCR)
Cryptic complex chromosome rearrangment (CCCR)
Micro-seq
Mate-pair sequencing
Preimplantation genetic testing (PGT)
Online Access:https://doi.org/10.1038/s41598-024-70566-5

Internet

https://doi.org/10.1038/s41598-024-70566-5

Similar Items