Bias-inducing allosteric binding site in mu-opioid receptor signaling
Abstract G-protein-biased agonism of the mu-opioid receptor (μ-OR) is emerging as a promising strategy in analgesia. A deep understanding of how biased agonists modulate and differentiate G-protein-coupled receptors (GPCR) signaling pathways and how this is transferred into the cell are open questio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2021-04-01
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| Series: | SN Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s42452-021-04505-8 |